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4-Hydroxy-N-methyl-N-ethyltryptamine, commonly referred to as 4-HO-MET, is a lesser-known psychedelic substance belonging to the tryptamine class. This compound is structurally related to psilocin, the active component found in psilocybin mushrooms, often known as "magic mushrooms." Its psychoactive effects are believed to arise from its interaction with serotonin receptors in the brain.

History and Synthesis

The synthesis of 4-HO-MET was first accomplished by the American chemist Alexander Shulgin, who documented his findings in the 1997 publication "TiHKAL" (Tryptamines I Have Known and Loved). Human usage reports began to emerge in the late 2000s, coinciding with its availability on the online research chemical market. It has been marketed alongside other psilocybin analogues, including 4-AcO-DMT and 4-HO-MiPT.

Subjective Effects

Users of 4-HO-MET often report a range of subjective effects, including geometric visual hallucinations, time distortion, enhanced introspection, and experiences of ego loss. Many describe 4-HO-MET as a more recreational alternative to psilocybin mushrooms, highlighting its less serious headspace and a stronger focus on visual effects. The psychedelic visuals associated with this substance are frequently described as vivid and colorful.

Chemical Structure

4-HO-MET is classified as a synthetic indole alkaloid within the tryptamine chemical class. Tryptamines are characterized by a core structure that includes a bicyclic indole heterocycle, which is connected at R3 to an amino group via an ethyl side chain. In the case of 4-HO-MET, a hydroxyl functional group (OH−) is substituted at R4 of its indole heterocycle. Additionally, it features a methyl group and an ethyl chain attached to the terminal amine of its tryptamine backbone.

Comparison with Other Compounds

4-HO-MET is recognized as a 4-hydroxy homolog of 4-AcO-MET and the N-substituted ethyl homolog of psilocin (4-HO-DMT). It also serves as the 4-hydroxyl analog of the base tryptamine MET.

Mechanism of Action

The psychedelic effects of 4-HO-MET are thought to stem from its activity as a partial agonist at the 5-HT2A receptor. However, the precise mechanisms behind these interactions and their contribution to the psychedelic experience are still under scientific investigation.

Dosing and Individual Variability

Anecdotal evidence suggests that the effective dose of 4-HO-MET can vary significantly among users. Some individuals report intense experiences with doses as low as 17 mg, while others may require doses as high as 30 mg for lighter effects. This variability may be influenced by individual differences in neurochemistry, metabolism, and the quality of the substance, including its physical forms (e.g., HCl vs. fumarate salt).

Conclusion

Users have reported that the experiences induced by 4-HO-MET often involve hallucinatory states characterized by waves of euphoria, alternating between moments of clarity and intense visual phenomena. Due to its strong visual effects and relatively low cognitive distress, 4-HO-MET is often viewed as a recreational and practical alternative to psilocybin mushrooms, sharing thematic similarities in visual experiences.

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4-HO-MET Fumarate Powder are strictly for research purposes only and not for human consumption.

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4-HO-MET Fumarate Powder stock last updated at: May 2026

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